Epigenomics

Epigenomics

Epigenomics is the study of the epigenome, or the whole set of epigenetic alterations on a cell's genetic material. The field is comparable to genomics and proteomics, which examine a cell's genome and proteome. Reversible alterations to a cell's DNA or histones that affect gene expression without changing the DNA sequence are known as epigenetic modifications. Epigenomic maintenance is an ongoing process that contributes to the stability of eukaryotic genomes by participating in critical biological systems such as DNA repair. Plant flavones are thought to inhibit cancer-causing epigenomic markers.  DNA methylation and histone modification are two of the most well-studied epigenetic changes. Epigenetic changes are engaged in a variety of cellular processes, including differentiation/development and cancer, and play a key role in gene expression and regulation. Epigenetics research on a worldwide scale has only lately been possible thanks to the application of genomic high-throughput techniques.

 

  • Protein identification and validation
  • Electrospray ionization mass spectrometry (ESI-MS)

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