Proteomics, Genomics & Bioinformatics

Structural Genomics

Structural Genomics

The goal of structural genomics is to describe the three-dimensional structure of each protein encoded by a genome. By combining experimental and modelling methodologies, this genome-based methodology provides for a high-throughput method of structure determination. The main distinction between structural genomics and standard structural prediction is that structural genomics tries to figure out the structure of every protein encoded by the genome rather than just one. Structure prediction can be done more quickly using a combination of experimental and modelling approaches now that full-genome sequences are available, especially because the availability of a large number of sequenced genomes and previously solved protein structures allows scientists to model protein structure on previously solved homologs.