Proteomics, Genomics & Bioinformatics

Proteomics in Biomedical Applications

Proteomics in Biomedical Applications

Proteomics has its origins in two-dimensional gel electrophoresis (2-DE), a technique developed more than twenty years ago. 2-DE has a high-resolution capacity, and was initially used primarily for separating and characterizing proteins in complex mixtures. 2-DE is still a useful method for identifying proteins, but it is now frequently used in conjunction with mass spectrometry (MS), a technique that has evolved significantly in recent years. The recent completion of the human genome project has resulted in a vast DNA database that can be used by bioinformatics, and the next task for scientists is to discover an organism's whole proteome. The integration of genomic and proteomic data will aid in the understanding of protein activities in disease pathogenesis and the ageing process, and may lead to the discovery of novel therapeutic target proteins and disease biomarkers. This study explores the possible applications of proteomics in biological research and describes current breakthroughs in proteomic technology.